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Professor Huo Yixin’s research team of BIT publishes latest research on Nature Communications

release date :2018-09-25 01:54:00  |   [ close window ]ViewCount:

  Translator: News Agency of BIT Chen Ruohang

  Editor: News Agency of BIT





  Global amino acid market shows an upward trend year by year. The annual CAGR was maintained at about 5.6%. The annual production of amino acid in 2016 had reached 8 million ton. The total sales had reached about 10 billion dollars. By microbial fermentation over 85% of the global production was produced because of its high productivity and low cost. How to screen, reform and obtain the amino acid overproduction strains has been the key problem of raising the fermentation production.


  On Sept. 6th, 2018, professor Huo Yixin’s research team, which is from the school of life science in BIT, published a research essay entitled Utilization of rare codon-rich markers for screening amino acid overproducers on Nature Group’s comprehensive journal Nature Communications (IF="12.353," the 7th journal with most of the academic impact according to Google Scholar,2018). The essay raised the “threshold” of the amino acid concentration that protein translation needs by increasing the quantity of rare codons in the sequence for the first time. The essay also made use of essential genes and colored proteins encoded by genes to set up amino acid overproduction strains selection and screening systems. What’s more, it also proved the feasibility of the method in Escherichia coli and Corynebacterium glutamicum. The research provided a new system for screening amino acid overproduction strains, which can solve the problem that the old methods have, such as high poisonousness, low positive rate and the limit of application objects. Theoretically, the system can be used at any natural amino acid overproductions strains screening. Meanwhile, it provides a new thinking for the discovery of amino acid overproduction systems, which can be used at the construction of good strains during the amino acids fermentation productions, and then propel the growth of amino acid market as well as promote the amino acid applied in the field of food, medicine and cultivation.



  1 Rare codons slow down translation rate and recovery



  2 Transcriptome analysis of gene expression changes


  Huo Yixin, professor of the School of Life Science of BIT, selectee of young overseas high-level talents introduction plan, is the correspondent of the essay. Zheng Bo, PhD of the School of Life Science of BIT and post-doctoral Ma Xiaoyan are joint first authors. Teacher and students such as special research fellow Yang Yu are joint authors. The research got the funding from Young overseas high-level talents introduction plan, NSFC, National Key R&D Plan and China Postdoctoral.


  Essay link:


  [About the author] Professor Huo Yixin had been studying and working at western research institutes and biotechnologies such as Institut Pasteur, University of California, Los Angeles and so on for 13 years. He had great experiences on basic research at academic as well as application and transportation research at industrial field. In Oct. 2015, he came to BIT and became a selectee of young overseas high-level talents introduction plan. The research team he is leading is under the theme of “microorganism refining and creation of natural resource” and the key of metabolic engineering. It gives top priority to “artificial cells factory’s design-construction-screening- amplification” and operate a series of research by making many kinds of living things as objects of study. So far the team has won lots of research results, and has published over 20 essays on many international famous journals such as Nature Biotechnology, Science, Nature Communication, Current Opinion in Biotechnology, Nucleic Acids Research, Metabolic Engineering, Applied Microbiology and Biotechnology, Molecular Microbiology and so on.


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